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EC number: 235-231-8 | CAS number: 12136-78-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Remarks:
- intratracheal and inhalation study, focus on collagen formation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative assessment of the effect on the organism of silicides of the transition metals
- Author:
- Brakhnova I.T. & Samsonov G.V.
- Year:
- 1 970
- Bibliographic source:
- Gig Sanit. 35(1), 42-45
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The intratracheal and inhalation effects of three substances were evaluated: TiSi2, MoSi2, WSi2.
- GLP compliance:
- no
- Type of method:
- in vivo
- Endpoint addressed:
- other: collagen formation in brain after intratracheal instillation
Test material
- Reference substance name:
- Molybdenum disilicide
- EC Number:
- 235-231-8
- EC Name:
- Molybdenum disilicide
- Cas Number:
- 12136-78-6
- Molecular formula:
- MoSi2
- IUPAC Name:
- molybdenum disilicide
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- other: intratracheal and inhalation
- Duration of treatment / exposure:
- 1 to 6 months
- Details on study design:
- The experiment was performed in the brain agar on rats, the duration of the experiment was 1-6 months.
Results and discussion
- Details on results:
- With intratracheal administration of MoSi2, the activity of collagen formation is 50% by the 6th months of the experiment. When inhaled for 3 months at an average concentration of 215 mg/m³, the formation of collagen was 42.7%. The following morphological changes were noted in animals: peribronchitis, perivascular, focal pneumonia, hyperplasia of the lymph nodes. In the kidneys, degeneration of the epithelium of renal tubules was observed. The renal capsules contained the exudate of a protein type. In some animals, dystrophic changes in the myocardium occurred. At a concentration of MoSi2 of 7.7 mg/m³, only minor disturbances were detected.
Applicant's summary and conclusion
- Executive summary:
In an experimental research study the intratracheal and inhalation effects of three substances (TiSi2, MoSi2, WSi2) were evaluated. The experiment was performed in the brain on rats. The duration of the experiment was 1-6 months. With intratracheal administration of MoSi2, the activity of collagen formation is 50% by the 6th months of the experiment. When inhaled for 3 months at an average concentration of 215 mg/m³, the formation of collagen was 42.7%. The following morphological changes were noted in animals: peribronchitis, perivascular, focal pneumonia, hyperplasia of the lymph nodes. In the kidneys, degeneration of the epithelium of renal tubules was observed. The renal capsules contained the exudate of a protein type. In some animals, dystrophic changes in the myocardium occurred. At a concentration of MoSi2 of 7.7 mg/m³, only minor disturbances were detected. The MPC of the working area air for MoSi2 is proposed at the level of 4 mg/m³.
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