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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics in vitro / ex vivo
Type of information:
experimental study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
GLUCURONIDE AND SULFATE CONJUGATION IN ISOLATED LIVER CELLS FROM CONTROL AND PHENO BARBITAL TREATED OR POLY CHLORINATED BI PHENYL TREATED RATS
Author:
Suolinna E-M and Mantyla E
Year:
1980
Bibliographic source:
Biochemical Pharmacology, (1980) Vol. 29, No. 21, pp. 2963-2968.

Materials and methods

Principles of method if other than guideline:
Glucuronidation and sulofonation was studied in isolated rat liver cells
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-aminophenol
EC Number:
202-431-1
EC Name:
2-aminophenol
Cas Number:
95-55-6
Molecular formula:
C6H7NO
IUPAC Name:
2-aminophenol
Test material form:
solid

Test animals

Species:
rat

Results and discussion

Applicant's summary and conclusion

Executive summary:

The conjugation of o-aminophenol was studied in isolated rat liver cells. For maximum sulfate conjugation to take place a very high sulfate concentration (50 mM) was needed, indicating that the rate limiting step may be the formation of active sulfate. Only a slight increase in the glucuronide/sulfate ratio with increasing substrate concentration was seen. Inducers of drug metabolism, PCB [polychlorinated biphenyl] and phenobarbital, increased only glucuronidation.