Registration Dossier
Registration Dossier
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EC number: 915-277-1 | CAS number: 32052-51-0
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Inhibition of cholinesterase activity by isocyanates
- Author:
- Brown WE, Green AH, Karol MH and Alarie YCE
- Year:
- 1 982
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 63, 45-52
Materials and methods
- Type of method:
- in vitro
Test material
- Reference substance name:
- Trimethylhexa-1,6-diyl diisocyanate
- EC Number:
- 249-151-6
- EC Name:
- Trimethylhexa-1,6-diyl diisocyanate
- Cas Number:
- 28679-16-5
- Molecular formula:
- C11H18N2O2
- IUPAC Name:
- 1,6-Diisocyanatotrimethylhexane
- Details on test material:
- Hexamethylene diisocyanate, toluene diisocyanate, hexyl isocyanate and other isocyanates (analogy)
Constituent 1
Results and discussion
- Details on results:
- In-vitro assays showed that all isocyanates tested were potent inhibitors of human cholinesterase activity. Hexamethylene diisocyanate was one of
the most active inhibitors in titration experiments (complete inhibition at molar ratios of 4:1 to 8:1 (isocyanate:enzyme)) or when applied as vapour
at 1 ppm. The authors conlude that this effect may be an explanation for the observed respiratory symptoms noted upon exposure to these
isocyanates.
Any other information on results incl. tables
no other information
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
