Registration Dossier
Registration Dossier
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EC number: 915-277-1 | CAS number: 32052-51-0
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
A Respiration Inhibition Test according to OECD Guideline No. 209 was carried out with 2,2,4(or 2,4,4)-trimethylhexane-1,6-diisocyanate with activated sludge of a municipal treatment plant as test system.
The test was carried out under static conditions with the nominal test item concentrations 0.32 - 1.0 - 3.2 - 10 - 32 - 100 mg/L. The respiration rates of the control, reference and test item replicates were measured after a contact time of three hours
and the mean inhibition of respiration for the test item replicates ranged from -3 % to 80 %. The NOEC of the test item is 3.2 mg/L, the EC50 is 17.9 mg/L
Validity criteria of the test guideline were fulfilled.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 17.9 mg/L
- EC10 or NOEC for microorganisms:
- 3.2 mg/L
Additional information
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