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EC number: 689-267-8 | CAS number: 501925-98-0
The test substance is not irritating to skin (LPT, 2013) or eyes (LPT, 2013).
Findings Examination Skin irritation scores
of the skin schedule
1 2 3
E/Oe E/Oe E/Oe
500 ml substance/patch/animal
eschar formations/ before dosing 0/0 0/0 0/0
time after removal
of the patch
60 min 0/0 0/0 0/0
24 hours 0/0 0/0 0/0
48 hours 0/0 0/0 0/0
72 hours 0/0 0/0 0/0
0 no pathological findings
E erythema and eschar formations
The purpose of this study was to examine the test substance for acute dermal irritation/corrosion properties in rabbits (patch test), according to OECD guideline 404, EC method B.4.and OCSPP guideline 870.2500.
Under the present test conditions, none of the three male rabbits exposed for 4 hours to 500 ml test item/patch (semi-occlusive conditions) showed any skin reaction. There were no systemic intolerance reactions. Therefore, the test substance was non-irritating to skin, hence no labelling is required.
Acute eye irritation/corrosion test of the test item
Examination of the treated eye
C O R N E A
I R I S
C O N J U N C T I V A E
A n i m a l n o. : 1 / 2 / 3
right eye: 100 ml test item
The purpose of this study was to obtain information on the influence of the test item on rabbit eyes (irritation/corrosion test), according to OECD guideline 405, EC method B.5. and OCSPP guideline 870.2400.
Under the present test conditions a single administration of the test item per animal into the conjunctival sac of the right eye of three rabbits did not cause any changes.
Conjunctival redness, corneaeandirises were not affected by instillation of the test item. There were no systemic intolerance reactions.Therefore, according to the EC Regulatiom 1272/2008 and subsequent regulations on classification, labelling and packaging of substances and mixtures, the test item is non-irritating to eyes, hence, no labelling is required.
Based on the assessment of two animal studies (skin and eye irritating) and according to criteria of EC Directive 67/548/EEC and EC Regulation 1272/2008 the test item is not irritating to skin and eyes.
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