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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report Date:
1975

Materials and methods

Principles of method if other than guideline:
Internal BASF method was used. A 50% aqueous preparation of the substance has been applied on the back and ear of rabbits for 20 hours, observations were reported after 24h, 48h, 5 days, 6 days 7 days and 8 days.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Physical state: solid

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: male 2.76 kg, female 3.03 kg

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
water
Controls:
no
Amount / concentration applied:
TEST MATERIAL
- Concentration (if solution): 50%
Duration of treatment / exposure:
20 h
Observation period:
24 h, 48 h, 5 d, 6 d, 7 d, 8 d
Number of animals:
2
Details on study design:
TEST SITE
- Area of exposure: back of animals
- Type of wrap if used: 2.5x2.5cm cotton lint moistened with test substance

REMOVAL OF TEST SUBSTANCE
- Washing (if done): with water
- Time after start of exposure: 20 h

SCORING SYSTEM:
The original BASF grading was converted into the numerical grading according to the OECD Draize system.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24, 48 h
Score:
0
Max. score:
4
Reversibility:
other: not applicable
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24, 48 h
Score:
0
Max. score:
4
Reversibility:
other: not applicable
Irritant / corrosive response data:
Yellow substance residues were reported.

Any other information on results incl. tables

Animal 1: male, 2.76 kg

Animal 2: female, 3.03 kg

Results:

Readings Animal Erythema Edema Additional findings
24 h 1 0 0 s
2 0 0 s
48 h 1 0 0 s
2 0 0 s
5d  1 0 0 s
2 0 0 s
6 d 1 0 0 s
2 0 0 s
7 d 1 0 0 s
2 0 0 s
8 d 1 0.0 0.0 s
2 0.0 0.0 s
mean 24 - 72 h 1 0.0 0.0  
2 0.0 0.0  
mean   0 0  

s: substance precipitation

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met