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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
data from modelling database
Qualifier:
equivalent or similar to
Guideline:
other: predicted data
Principles of method if other than guideline:
To estimate the partition coefficient of the test chemical using KOWWIN model from EPISUITE
GLP compliance:
not specified
Type of method:
other: predicted data
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
- Name of test material (as cited in study report): Piperazine citrate / tripiperazine dicitrate- Molecular formula: C12H30N6•Cl2H16O14 - Molecular weight: 642.76 g/mole - Substance type: Organic - Physical state: Solid
Analytical method:
not specified
Key result
Type:
log Pow
Partition coefficient:
-1.15
Remarks on result:
other: no additional details mentioned
Conclusions:
The octanol water partition coefficient of the test chemical was estimated using KOWWIN model from EPISUITE. The estimated log Pow of piperazine citrate was -1.15.
Executive summary:

The octanol water partition coefficient of the test chemical was estimated using KOWWIN model from EPISUITE.

The estimated logPow of piperazine citrate was -1.15.

Based on this value, piperazine citrate can be considered to be hydrophillic in nature, which is also supported by the water solubility of the test chemical.

Description of key information

The octanol water partition coefficient of the test chemical was estimated using KOWWIN model from EPISUITE. The estimated log Pow of piperazine citrate was -1.15.

Key value for chemical safety assessment

Log Kow (Log Pow):
-1.15

Additional information

The octanol water partition coefficient of the test chemical was estimated using KOWWIN model from EPISUITE. The estimated logPow of piperazine citrate was -1.15. Based on this value, piperazine citrate can be considered to be hydrophillic in nature, which is also supported by the water solubility of the test chemical.