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Physical & Chemical properties

Explosiveness

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Reference
Endpoint:
explosive properties of explosives
Data waiving:
other justification
Justification for data waiving:
the study does not need to be conducted because there are no chemical groups present in the molecule which are associated with explosive properties
the study does not need to be conducted because the substance contains chemical groups associated with explosive properties which include oxygen, but the calculated oxygen balance is less than - 200
other:
Justification for type of information:
JUSTIFICATION FOR DATA WAIVING
In accordance with REACH Regulation (EC) No. 1907/2006 Annex VII, column 2 section 7.11 the study does not need to be conducted based on structural assessment of the substance. The substance constituents do not contain groups associated with explosive properties and additionally the calculated oxygen balance for each constituent is < - 200. Additionally, the known impurities have been further assessed and whilst one impurity possesses an oxygen balance of > -200 it does not contain a Nitro-group or any other structural alert. Oxidation of amino-groups of parent structures is not expected to occur during use and furthermore would not by expert judgement be expected to be able to contribute to explosive property due to the absence of direct explosive property structural alerts (as defined in Bretherick, 1999). Furthermore, handling and use of the substance confirm that the substance does not have explosive properties. According to ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7a: Endpoint Specific Guidance, R.7.1.11, December 2016) the study does not need to be conducted.
References:
1. Bretherick (1999) Bretherick’s Handbook of Chemical Reactive Hazards: An Indexed Guide to Published Data, 6th Edition (2 volume set)
2. ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7a: Endpoint Specific Guidance, R.7.1.11.1, December 2016)
3. ECHA Guidance on Application on the CLP Criteria, section 2.6 (v4.1, June 2015)

Description of key information

Explosiveness: non-explosive; based on structural assessment of the substance.

Key value for chemical safety assessment

Explosiveness:
non explosive

Additional information

In accordance with REACH Regulation (EC) No. 1907/2006 Annex VII, column 2 section 7.11 the study does not need to be conducted based on structural assessment of the substance. The substance constituents do not contain groups associated with explosive properties and additionally the calculated oxygen balance for each constituent is < - 200. Additionally, the known impurities have been further assessed and whilst one impurity possesses an oxygen balance of > -200 it does not contain a Nitro-group or any other structural alert. Oxidation of amino-groups of parent structures is not expected to occur during use and furthermore would not by expert judgement be expected to be able to contribute to explosive property due to the absence of direct explosive property structural alerts (as defined in Bretherick, 1999). Furthermore, handling and use of the substance confirm that the substance does not have explosive properties. According to ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7a: Endpoint Specific Guidance, R.7.1.11, December 2016) the study does not need to be conducted.

References:

1. Bretherick (1999) Bretherick’s Handbook of Chemical Reactive Hazards: An Indexed Guide to Published Data, 6th Edition (2 volume set)

2. ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7a: Endpoint Specific Guidance, R.7.1.11.1, December 2016)

3. ECHA Guidance on Application on the CLP Criteria, section 2.6 (v4.1, June 2015)

Justification for classification or non-classification

The substance does not meet classification criteria under Regulation (EC) No 1272/2008 for explosivity.