Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-005-2 | CAS number: 9003-35-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal.
Data source
Reference
- Reference Type:
- publication
- Title:
- A single accidental exposure may result in a chemical burn, primary sensitization and allergic contact dermatitis.
- Author:
- Lasse Kanerva, Kyllikki Tarvainen, Anne Pinola, Timo Leino, Håkan Granlund, Tuula Estlander, Ritta Jolanki, Lars Förström
- Year:
- 1 994
- Bibliographic source:
- Contact Dermatitis, Vol. 31, No. 4, pages 229-235, 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Patch test
- Principles of method if other than guideline:
- Patch test was performed to study the skin sensitization potential of the test chemical.
- GLP compliance:
- not specified
- Type of study:
- patch test
- Justification for non-LLNA method:
- not specified
Test material
- Reference substance name:
- Formaldehyde, oligomeric reaction products with phenol
- EC Number:
- 500-005-2
- EC Name:
- Formaldehyde, oligomeric reaction products with phenol
- Cas Number:
- 9003-35-4
- Molecular formula:
- (C6H6O.CH2O)x
- IUPAC Name:
- Formaldehyde, oligomeric reaction products with phenol
- Details on test material:
- - Name of test material (as cited in study report): Phenol-formaldehyde resin
- Molecular formula: C6H6O.CH2O)x-
- Molecular weight: 34.133 g/mol
- Substance type: organic
- Physical state: solid
- Smiles notation: c1(c(c(ccc1)[CH])O)O[CH]
- InChl: 1S/C8H6O2/c1-6-4-3-5-7(10-2)8(6)9/h1-5,9H
Constituent 1
In vivo test system
Test animals
- Species:
- other: human
- Strain:
- not specified
- Sex:
- male
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: The Skin and Allergy Hospital,University of Helsinki, Finland
-Occupation: Mold worker
- Age at study initiation: 44 year
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 2.5 and 5% in petrolatum
- Adequacy of induction:
- not specified
Challenge
- No.:
- #1
- Route:
- epicutaneous, occlusive
- Vehicle:
- petrolatum
- Concentration / amount:
- 2.5 and 5% in petrolatum
- Adequacy of challenge:
- not specified
- No. of animals per dose:
- 1 human
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: single
- Exposure period: no data available
- Test groups: test group
- Concentrations: 2.5 and 5% in petrolatum
B. CHALLENGE EXPOSURE
- No. of exposures: single
- Test groups: test group
- Concentrations: 2.5 and 5% in petrolatum
- Evaluation (hr after challenge): no data available
OTHER: A mold worker was accidentally exposed to the test chemical when he lifted a barrel assumed to be empty. A liquid containing Urea-formaldehyde resin and free formaldehyde splashed on his face, hands and legs. He quickly washed the exposed areas with copious amount of water and took a shower. After 1 week, he developed eczema on the exposed areas.
Patch testing was performed at University Clinic. Allergic patch test reactions were provoked by the resin used at work and by Phenol-formaldehyde resin [PFR] (P-F-R, Epikon, 1+). After 2 years the patient developed eczema, cough, fever, respiratory distress. Investigations at the Institute revealed occupational asthma and allergic alveolitis. The patient was re-tested with various P-F-Rs.
P-F-Rs from Chemotechnique (2.5 and 5% in petrolatum) and P-F-R novolak from Hermal Chemie(5% petrolatum) produced a 3+ reaction.
Results and discussion
In vivo (non-LLNA)
Results
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 168
- Group:
- test chemical
- Dose level:
- 35 % urea phenol formaldehyde resin and 0.5% free formaldehyde
- No. with + reactions:
- 1
- Total no. in group:
- 1
- Clinical observations:
- Patient develops eczema on the exposed surface after 7 days. 2 year later he developed cough, respiratory distress, fever and eczema
- Remarks on result:
- positive indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- other: Sensitizing
- Conclusions:
- P-F-Rs from Chemotechnique (2.5 and 5% in petrolatum) and P-F-R novolak from Hermal Chemie(5% petrolatum) produced a 3+ reaction.
It was concluded that the patient developed allergic reactions due to various P-F-Rs.
Hence, the test chemical can be considered to be sensitizing to skin. - Executive summary:
Patch test was performed to study the skin sensitization potential of the test chemical.
A mold worker was accidentally exposed to the test chemical when he lifted a barrel assumed to be empty. A liquid containing Urea-formaldehyde resin and free formaldehyde splashed on his face, hands and legs. He quickly washed the exposed areas with copious amount of water and took a shower. After 1 week, he developed eczema on the exposed areas.
Patch testing was performed at University Clinic. Allergic patch test reactions were provoked by the resin used at work and by Phenol-formaldehyde resin [PFR] (P-F-R, Epikon, 1+). After 2 years the patient developed eczema, cough, fever, respiratory distress. Investigations at the Institute revealed occupational asthma and allergic alveolitis. The patient was re-tested with various P-F-Rs.
P-F-Rs from Chemotechnique (2.5 and 5% in petrolatum) and P-F-R novolak from Hermal Chemie(5% petrolatum) produced a 3+ reaction.
It was concluded that the patient developed allergic reactions due to various P-F-Rs.
Hence, the test chemical can be considered to be sensitizing to skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.