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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2008-03-03 till 2008-03-04
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline-conform study under GLP without deviations.
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
92/69/EWG, A.8 (estimation from single solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water
Key result
Type:
log Pow
Partition coefficient:
< -3.79
Temp.:
22 °C
pH:
ca. 7

Estimation from single solubility in n-octanol and water.

Conclusions:
From the experimental data obtained it can be concluded that the affinity of the sample of the test substance is much higher for water than its affinity for n-octanol (Pow < 1.61x 10-4 , log Pow < -3.79).

Description of key information

-3.79 at 22 °C

Key value for chemical safety assessment

Log Kow (Log Pow):
-3.79
at the temperature of:
22 °C

Additional information