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Ecotoxicological information

Toxicity to microorganisms

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Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two toxicity to micro-organism studies as-
2. and 3.
GLP compliance:
not specified
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: 2. Tetrahymena pyriformis and 3. Vibrio fisheri
Test type:
static
Water media type:
freshwater
Remarks:
2. freshwater and 3. saltwater
Total exposure duration:
30 min
Reference substance (positive control):
not specified
Dose descriptor:
IC50
Effect conc.:
0.5 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: 2. Other details not known
Duration:
30 min
Dose descriptor:
other: EC20
Effect conc.:
0.5 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
other: Luminescence
Remarks on result:
other: 3.
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, both the IC50 and EC20 value the test chemical on the test organism was observed to be 0.5 mg/l.
Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxic effect of the test chemical on micro-organisms.The studies are as mentioned below:

The test material was evaluated for its antimicrobial effect on Tetrahymena pyriformis. The inhibitory effect concentration (IC50) for Tetrahymena pyriformis was observed to be 0.5 mg/l . Nonetheless, the test material also inhibited the protozoan reproduction.

For the test chemical, another short term toxicity toVibrio fischeri study was carried out.The study was performed in accordance with the standard method ‘DIN 38412 Part 34’. On the basis of the effect of test chemical on luminescence of the test organism Vibrio fischeri, the EC20 value was determined to be 0.5 mg/l.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, both the IC50 and EC20 value the test chemical on the test organism was observed to be 0.5 mg/l.

Description of key information

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, both the IC50 and EC20 value the test chemical on the test organism was observed to be 0.5 mg/l.

Key value for chemical safety assessment

EC50 for microorganisms:
0.5 mg/L

Additional information

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxic effect of the test chemical on micro-organisms. The studies are as mentioned below:

 

The test material was evaluated for its antimicrobial effect on Tetrahymena pyriformis. The inhibitory effect concentration (IC50) for Tetrahymena pyriformis was observed to be 0.5 mg/l . Nonetheless, the test material also inhibited the protozoan reproduction.

 

For the test chemical, another short term toxicity to Vibrio fischeri study was carried out.The study was performed in accordance with the standard method ‘DIN 38412 Part 34’. On the basis of the effect of test chemical on luminescence of the test organism Vibrio fischeri, the EC20 value was determined to be 0.5 mg/l.

 

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, both the IC50 and EC20 value the test chemical on the test organism was observed to be 0.5 mg/l.