Registration Dossier
Registration Dossier
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EC number: 200-562-9 | CAS number: 63-68-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
L-methionine is a normal constituent in living cells occurring as a free amino acid, bound to RNA and incorporated in proteins and peptides. Available mutation/genotoxicty studies did not reveal a mutagenic activity of L-methionine.Also read-across data of D,L-methionine seems to be relevant for the assessment of L-methionine due to structural and physico-chemical similarities according to Reach regulation (Annex XI, 1.5) especially as L-methionine is present in a considerable amount in racemic methionine (approximately 50%). Taking all available information together L-methionine as well as D,L-methionine give not rise to safety concern with respect to genotoxicity.
These results were foreseeable as L-methionine is a naturally occurring none essential amino acid which is present in significant amounts in human body fluids (e g human blood plasma 25 +/- 4 µM - LA Cynober 2002) as well as in human cells. L-Methionine is ingested daily in a significant amount therefore human exposure through food is orders of magnitude higher than the anticipated levels of exposure from the uses covered by this dossier. L-Methionine is a basic metabolite and building block of all living organisms and therefore a genotoxic/mutagenic potential could be excluded.
Literature:
Cynober L (2002): Plasma Amino Acid Levels With a Note on Membrane Transport: Characteristics, Regulation, and Metabolic Significance. Nutrition 18 (9), 761-766
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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