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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Data is from peer-reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: AnisyL Formate
Author:
Not mentioned
Year:
1976
Bibliographic source:
Food and Cosmetics Toxicology Volume 14, Supplement, 1976, Page 685.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: refer below
Principles of method if other than guideline:
The acute toxicity study was conducted to evaluate the toxic effects of administration of Anisyl formate (CAS No. 122-91-8) in rat by the oral route.
GLP compliance:
not specified
Test type:
other: No data available
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Anisyl formate
EC Number:
204-582-9
EC Name:
Anisyl formate
Cas Number:
122-91-8
Molecular formula:
C9H10O3
IUPAC Name:
(4-methoxyphenyl)methyl formate
Test material form:
liquid
Details on test material:
- Name of test material: (4-methoxyphenyl)methyl formate
- Molecular formula: C9H10O3
- Molecular weight: 166.175 g/mol
- Smiles notation: c1(ccc(OC)cc1)COC=O
- InChl: 1S/C9H10O3/c1-11-9-4-2-8(3-5-9)6-12-7-10/h2-5,7H,6H2,1H3
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material: (4-methoxyphenyl)methyl formate
- Molecular formula: C9H10O3
- Molecular weight: 166.175 g/mol
- Smiles notation: c1(ccc(OC)cc1)COC=O
- InChl: 1S/C9H10O3/c1-11-9-4-2-8(3-5-9)6-12-7-10/h2-5,7H,6H2,1H3
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
No data available
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 150 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50% mortality observed.
Mortality:
No data available
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: Category 4 based on CLP criteria
Conclusions:
The acute oral median lethal dose (LD50) of anisyl formate in rat was observed to be 1150.0 mg/kg b.wt.
Executive summary:

The acute toxicity study was conducted to evaluate the toxic effects of administration of Anisyl formate (CAS No. 122-91-8) in rat by the oral route. 50% mortality was observed at 1150.0 mg/kg b.wt in treated rats. The acute oral median lethal dose (LD50) of anisyl formate in rat was observed to be 1150.0 mg/kg b.wt. Thus, by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Anisyl formate (CAS No. 122 -91-8) can be classify under category 4 compound at the tested dose levels.