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Ecotoxicological information

Long-term toxicity to fish

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Reference
Endpoint:
long-term toxicity to fish, other
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to
Guideline:
other: Modelling database
Principles of method if other than guideline:
Long term toxicity to fish was carried out according to the EPISUITE, ECOSAR.
GLP compliance:
not specified
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: Fish
Test type:
static
Water media type:
freshwater
Total exposure duration:
28 d
Reference substance (positive control):
not specified
Key result
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
0.343 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Neutral Organics SAR (Baseline toxicity)
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of no effects observed in a static freshwater system, the NOEC value for the substance is estimated to be 0.343 mg/l for fish for 28 days of exposure duration
Executive summary:

Based on the prediction done using ECOSAR class, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a static freshwater system, the NOEC value for the substance is estimated to be 0.343 mg/l for fish for 28 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to fish at environmentally relevant concentrations and can be considered to be classified in aquatic chronic 2 category as per the CLP classification criteria. 

Description of key information

Based on the prediction done using ECOSAR class, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a static freshwater system, the NOEC value for the substance is estimated to be 0.343 mg/l for fish for 28 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to fish at environmentally relevant concentrations and can be considered to be classified in aquatic chronic 2 category as per the CLP classification criteria. 

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater fish:
0.343 mg/L

Additional information

Based on the prediction done using ECOSAR class, the long term toxicity on fish was predicted for test substance. On the basis of no effects observed in a static freshwater system, the NOEC value for the substance is estimated to be 0.343 mg/l for fish for 28 days of exposure duration. Based on this value, it can be concluded that the test chemical can be considered as toxic to fish at environmentally relevant concentrations and can be considered to be classified in aquatic chronic 2 category as per the CLP classification criteria.