Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative databases

Data source

Reference
Reference Type:
other: Authoritative database
Title:
HSDB for the CAS: 123-43-3
Author:
U.S National Library Medicine
Year:
2003
Bibliographic source:
Hazardous Substances Databank (HSDB), U.S National Library Medicine, last updated 2003

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To assess the ocular irritation potential of sulfoacetic acid in rabbits
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sulphoacetic acid
EC Number:
204-627-2
EC Name:
Sulphoacetic acid
Cas Number:
123-43-3
Molecular formula:
C2H4O5S
IUPAC Name:
2-sulfoacetic acid
Test material form:
solid
Details on test material:
- Name of test material : Sulfoacetic acid
- Molecular formula: C2H4O5S
- Molecular weight : 140.115g/mole
- Substance type:organic
- Physical state:solid
Specific details on test material used for the study:
- Name of test material: Sulfoacetic acid
- Molecular formula: C2H4O5S
- Molecular weight: 140.115g/mole
- Substance type: organic
- Physical state: solid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
no data available
Duration of treatment / exposure:
24 hours
Observation period (in vivo):
24 hours
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
SCORING SYSTEM: Ocular reactions were rated on scale of 1 to 10 according to degree of injury observed after 24 hr, paying particular attention to condition of cornea. Most severe injuries have been rated 10.

Results and discussion

In vitro

Other effects / acceptance of results:
no data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Score:
9
Max. score:
10
Reversibility:
not specified
Remarks on result:
probability of severe irritation
Irritant / corrosive response data:
Severe irritation observed

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
Sulfoacetic acid was rated 9 on a scale of 1-10. Most severe injuries are rated 10
Hence based on the scores, sulfoacetic acid can be considered severely irritating to rabbit eyes.
Executive summary:

An eye irritation study was carried out in rabbits to assess the eye irritation potential of sulfoacetic acid. Sulfoacetic acid was instilled into rabbit eyes and observed for signs of irritation till 24 hours.Ocular reactions were rated on scale of 1 to 10 according to degree of injury observed after 24 hr, paying particular attention to condition of cornea.

Sulfoacetic acid was rated 9 on a scale of 1-10.Most severe injuries have been rated 10.

Hence based on the scores, sulfoacetic acid can be considered severely irritating to rabbit eyes.