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EC number: 281-619-5 | CAS number: 84000-63-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from peer-reviewed journal.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Lifetime toxicity/carcinogenicity study of FD & C Red No. 40 (Allura Red) in Sprague-Dawley rats
- Author:
- J.F. Borzelleca; J.W. Olson; F.E. Reno
- Year:
- 1 989
- Bibliographic source:
- Food and Chemical Toxicology Volume 27, Issue 11, 1989, Pages 701–705
- Reference Type:
- publication
- Title:
- Acute dermal application - rabbits, Red Z-4576.
- Author:
- Weir, R. J.
- Year:
- 1 967
- Bibliographic source:
- Unpublished report 165-119 by Hazelton Laboratories, Inc., submitted by Allied Chemical Corporation, 1967
- Reference Type:
- review article or handbook
- Title:
- DPIM: FAG100
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials);FCTOD7Food and Chemical Toxicology. 27 (1989), 701.
Materials and methods
- Principles of method if other than guideline:
- The toxicity study was examined to evaluate the acute toxic effects of administration of disodium 6-hydroxy-5-[(2-methoxy-4- sulphonato- m-tolyl) azo]naphthalene-2-sulphonate (ALLURA RED AC) (CAS No. 25956-17-6) in rabbits by the dermal route.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Disodium 6-hydroxy-5-[(2-methoxy-4-sulphonato-m-tolyl)azo]naphthalene-2-sulphonate
- EC Number:
- 247-368-0
- EC Name:
- Disodium 6-hydroxy-5-[(2-methoxy-4-sulphonato-m-tolyl)azo]naphthalene-2-sulphonate
- Cas Number:
- 25956-17-6
- Molecular formula:
- C18H16N2O8S2.2Na
- IUPAC Name:
- disodium 6-hydroxy-5-[(2-methoxy-3-methyl-4-sulfonatophenyl)diazenyl]naphthalene-2-sulfonate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material : disodium 6-hydroxy-5-[(2-methoxy-4-sulphonato-m-tolyl)azo]naphthalene-2-sulphonate (ALLURA RED AC)
- Substance type: Organic
- Physical state: solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Doses:
- 0,316, 1.0, 3.16 and 10 g/kg bw (0,316, 1000, 3160, 10000mg/kg bw/day)
- No. of animals per sex per dose:
- 4 animals per group
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The acute dermal median lethal dose (LD50) of disodium 6-hydroxy -5-[(2-methoxy-4-sulphonato-m-tolyl)azo]naphthalene-2-sulphonate (ALLURA RED AC) in rabbit was observed to be >10000 mg/kg of body weight. Thus, according to CLP criteria for acute toxicity rating for the chemicals, it infers that disodium 6-hydroxy-5 -[(2-methoxy-4-sulphonato-m-tolyl)azo] naphthalene-2- sulphonate (ALLURA RED AC) (CAS No. 25956-17-6) does not classify as an acute dermal toxicant.
- Executive summary:
The toxicity study was examined to evaluate the acute toxic effects of administration of disodium 6-hydroxy-5-[(2-methoxy-4-sulphonato-m-tolyl)azo]naphthalene -2-sulphonate (ALLURA RED AC) (CAS No. 25956-17-6) in rabbits by the dermal route. The acute dermal median lethal dose (LD50) of disodium 6-hydroxy -5-[(2-methoxy-4-sulphonato-m-tolyl)azo]naphthalene-2-sulphonate (ALLURA RED AC) in rabbit was observed to be >10000 mg/kg of body weight. Thus, according to CLP criteria for acute toxicity rating for the chemicals, it infers that disodium 6-hydroxy-5 -[(2-methoxy-4-sulphonato-m-tolyl)azo] naphthalene-2- sulphonate (ALLURA RED AC) (CAS No. 25956-17-6) does not classify as an acute dermal toxicant.
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