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Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: as reported in source record
Justification for type of information:
see attachment "Read-across justification-environ assessment-iron oxides" and “Endpoint-specific read-across justification for nano forms of iron oxide, 2021” attached in IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
>= 100 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: as reported in source record

Description of key information

Applying read-across to nanosizediron(hydr)oxides (see attachment "Read-across justification-environ assessment-iron oxides" and “Endpoint-specific read-across justification for nano forms of iron oxide, 2021” attached in IUCLID section 13), nanosized iron manganese trioxide is not considered acutely toxic to fish. Respective 96-h LC50 values for the toxicity of nanosized iron (hydr)oxides to Danio rerio range from > 10,000 mg/L to > 100,000 mg/L, a concentration that is 1000-fold above the corresponding OECD test limit.

Key value for chemical safety assessment

Additional information

Acute toxicity of iron(hydr)oxidenanoforms was investigated in two reliable studies using nanosized diiron trioxide (Weyers, 1985) and iron hydroxide oxide yellow (Weyers & Caspers, 1989). Acute toxicity ofnano-alphadiiron trioxide was investigated under static conditions in accordance with the proposed procedure for lethal effect on Zebrabaerbling (Federal Environmental Agency Germany, May 1984) and an unbounded 96 h LC50 of > 10 g/L (nominal) was derived. Fornano-alphairon hydroxide oxide yellow within 96 hours no effects (LC0) on Danio rerio were observed up to a concentration of 100 g/L. The method used was a proposed procedure for lethal effect on Zebrabaerbling (Federal Environmental Agency Germany, May 1984).

Based on read-across to nanosized iron (hydr)oxides (see attachment "Read-across justification-environ assessment-iron oxides" and “Endpoint-specific read-across justification for nano forms of iron oxide, 2021” attached in IUCLID section 13), available data indicate a low potential for acute aquatic toxicity ofnanosized iron manganese trioxideto fish (see table below).Acute toxicity of nanosizediron (hydr)oxidesto fish was not observed up to 100 g/L (Weyers & Caspers, 1989), a concentration that is 1000-fold above the corresponding OECD test limit for acute toxicity.

 

Table: Acute aquatic toxicity of nanosized iron(hydr)oxidesto fish.

Endpoint

Test species

Test results

Test material/form

Reliability: Reference

Short-term toxicity to fish

Danio rerio

LC50 (96h): > 10 g/L nominal

LC0 (96h): >= 10 g/L nominal

diiron trioxide / nano, alpha

RL2: Weyers, 1985

.

Danio rerio

LC50 (96h): > 100 g/L nominal

LC0 (96h): >= 100 g/L nominal

iron hydroxide oxide yellow / nano, alpha

RL2: Weyers & Caspers, 1989

 

Supportive information microsized iron (hydr)oxides

Respective 96-h LC50 values for the toxicity of microsized iron (hydr)oxides to Danio rerio range from > 10,000 mg/L to > 100,000 mg/L, a concentration that is 1000-fold above the corresponding OECD test limit.