Fluocortolone

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

22 Oct 2015 - 25 Feb 2016

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

other: EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

Qualifier:

equivalent or similar to guideline

Guideline:

other: OECD Guideline 102 (Melting point / Melting Range)

Deviations:

not applicable

GLP compliance:

no

Type of method:

differential thermal analysis

Remarks:

Differential Thermal Analysis (DTA) / Differential Scanning Calorimetry (DSC)

Key result

Remarks on result:

other: Since there were no further evidences for a boiling point or range it can be stated that the test item has no boiling point

RESULT:

- A melting point between 110 and 200 °C could be observed due to the detected endothermal effect

- After the melting of the test item an exothermal phase could be observed between around 220 and 310 °C

-Due to the black colored residue in the crucible after the test the exothermic phase could indicate a decomposition

- Up to the decomposition of the test item no definite boiling point was observed

 

Validity criteria for the measurement of the boiling point:

Target condition according to guideline OECD 103:	Actual condition according to the study:	Validity criteria met:
The mean of at least two measurements which are in the range of the estimated accuracy (Siwoloboff = +/- 2.0 K) should be reported.	Only one value is reported, but a control is reported.	Yes, with restrictions.
The pressure(s) at which the measurements were made shall be reported. The pressure should preferably be close to normal atmospheric pressure.	The atmospheric pressure is  stated.	Yes

Conclusions:

Since there were no further evidences for a boiling point or range of the test item it can be stated that the test item has no boiling point.

Executive summary:

A differential thermoanalysis method (DTA) was used to determine the melting point which confirms with the procedure Test method A.2, "Determination of the melting point", described in the EC-Guideline. Between approx. 110 °C – 200 °C an endothermic phase could be detected which indicates the melting point of the test item. After the melting process the test item shows an exothermic phase between approx. 220 °C and 310 °C. Due to the black colored residue in the crucible after the test the exothermic phase could indicate a decomposition of the test item. Since there were no further evidences for a boiling point or range of the test item it can be stated that the test item has no boiling point.

Description of key information

A differential thermoanalysis method (DTA) was used to determine the melting point which confirms with the procedure Test method A.2, "Determination of the melting point", described in the EC-Guideline. Between approx. 110 °C – 200 °C an endothermic phase could be detected which indicates the melting point of the test item. After the melting process the test item shows an exothermic phase between approx. 220 °C and 310 °C. Due to the black colored residue in the crucible after the test the exothermic phase could indicate a decomposition of the test item. Since there were no further evidences for a boiling point or range of the test item it can be stated that the test item has no boiling point.

Additional information

After the melting process the test item shows an exothermic phase between approx. 220 °C and 310 °C. Due to the black colored residue in the crucible after the test the exothermic phase could indicate a decomposition of the substance.