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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Feb 1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Oral incubation of 4-5 week old mice.
GLP compliance:
no
Test type:
other: Acceptable methodology in the 1970's prior to OECD 401.

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl oct-2-ynoate
EC Number:
203-836-6
EC Name:
Methyl oct-2-ynoate
Cas Number:
111-12-6
Molecular formula:
C9H14O2
IUPAC Name:
methyl oct-2-ynoate
Test material form:
liquid

Test animals

Species:
mouse
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
water
Doses:
10.0 mL/kg body weight
5.0 mL/kg body weight
2.0 mL/kg body weight
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 5 - <= 10 mL/kg bw
Based on:
test mat.
Mortality:
Yes at 5 mL/kg and 10 mL/kg.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The mouse LD50 was considered to be between 5 mL/kg and 10 mL/kg.
No classification as no deaths were observed when tested upto Cat.4.