Registration Dossier
Registration Dossier
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EC number: 202-616-7 | CAS number: 97-89-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data s from peer- reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Fragrance raw materials monographs
- Author:
- D. L. J. Opdyke
- Year:
- 1 978
- Bibliographic source:
- Food and Cosmetics Toxicology
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Acute dermal toxicity study of test chemical in rabbit.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,7-dimethyloct-6-enyl isobutyrate
- EC Number:
- 202-616-7
- EC Name:
- 3,7-dimethyloct-6-enyl isobutyrate
- Cas Number:
- 97-89-2
- Molecular formula:
- C14H26O2
- IUPAC Name:
- 3,7-dimethyloct-6-enyl isobutyrate
- Details on test material:
- - Name of test material: Citronellyl isobutyrate
- IUPAC name: 3, 7-dimethyloct-6-en-1-yl 2-methylpropanoate
- Molecular formula: C14H26O2
- Molecular weight: 226.3574 g/mol
- Substance type: Organic
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality was observed in treated rat at 5000 mg/kg bw
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be > 5000 mg/kg bw when rabbits were treated with test chemical dermally.
- Executive summary:
In acute dermal toxicity study, rabbits were treated with test chemical in the concentration of 5000 mg/kg bw orally. No mortality was observed at 5000 mg/kg bw in treated rabbits. Therefore, LD50 was considered to be > 5000 mg/kg bw when rabbits were treated with test chemical dermally.
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