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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from review article or handbook

Data source

Reference
Reference Type:
review article or handbook
Title:
Tetrahydrothiophene [MAK Value Documentation, 2010a]
Author:
MAK Value Documentation
Year:
2012
Bibliographic source:
Tetrahydrothiophene [MAK Value Documentation, 2010a]. The MAK Collection for Occupational Health and Safety. 292–303; 2012.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
An eye irritation potential of Tetrahydrothiophene (CAS No: 110-01-0) was assessed in six albino rabbits to observed its irritating effects.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Details on test material:
- Name of test material (as cited in study report): tetrahydrothiophene
- Molecular formula: C4H8S
- Molecular weight: 88.1732 g/mol
- Substance type: organic
- Physical state: Solid
- Smiles notation: C1CCSC1
- InChl: 1S/C4H8S/c1-2-4-5-3-1/h1-4H2
Specific details on test material used for the study:
- Name of test material (as cited in study report): tetrahydrothiophene
- Molecular formula: C4H8S
- Molecular weight: 88.1732 g/mol
- Substance type: organic
- Physical state: Solid
- Smiles notation: C1CCSC1
- InChl: 1S/C4H8S/c1-2-4-5-3-1/h1-4H2

Test animals / tissue source

Species:
rabbit
Strain:
other: Albino
Details on test animals or tissues and environmental conditions:
No Data Available

Test system

Vehicle:
not specified
Controls:
other: The untreated eyes served as controls.
Amount / concentration applied:
Amount: 0.1 ml
concentration applied:100mg
Duration of treatment / exposure:
24hours

Observation period (in vivo):
24hours
Number of animals or in vitro replicates:
6
Details on study design:
- Area of exposure: conjunctival sac of one of both eyes

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Score:
0
Reversibility:
fully reversible
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
The instillation caused pain and blepharospasms. Severe inflammation, chemosis and slightly deepened folds of the iris were observed during the first four hours. Twenty-four hours after the treatment, only mild inflammation of the conjunctiva was still visible

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The test material Tetrahydrothiophene (CAS No: 110-01-0) was considered to be not irritating to the eye of six albino rabbits.
Executive summary:

An eye irritation potential of Tetrahydrothiophene (CAS No: 110-01-0) was assessed in six albino rabbits to observed its irritating effects.

 

In this test, 0.1 ml (100 mg) tetrahydrothiophene was instilled into the conjunctival sac of one of both eyes and later ocular lesions were noted.

 

The instillation caused pain and blepharospasms. Severe inflammation, chemosis and slightly deepened folds of the iris were observed during the first four hours. Twenty-four hours after the treatment, only mild inflammation of the conjunctiva was still visible.

 

Since the ocular lesions were not persisted after 24 hours,the test materialTetrahydrothiophene (CAS No: 110-01-0)was considered to be not irritatingto the eye of six albino rabbits.