Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Acute oral toxicity for CAS no.67-52-7
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemID plus A TOXNET DATABASE.2017

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
other: As mention below
Principles of method if other than guideline:
Acute oral toxicity study of Barbituric acid was performed in Rat
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report):Barbituric acid
- Molecular formula :C4H4N2O3
- Molecular weight :128.087g/mole
- Substance type:organic
- Physical state:Liquid
Purity:No data available
- Impurities (identity and concentrations):No data available
Specific details on test material used for the study:
- Name of test material (as cited in study report):Barbituric acid
- Molecular formula :C4H4N2O3
- Molecular weight :128.087g/mole
- Substance type:organic
- Physical state:Liquid
- Purity:No data available
- Impurities (identity and concentrations):No data available

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
5000 mg/kg
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
LD50 was considered >5000mg/kg body weight.When rats were treated with Barbituric acid orally.
Executive summary:

Acute oral toxicity study, rats were treated with Barbituric acid orally. No mortality was observed in treated rats at 5000 mg/kg bw. Therefore, LD50 was considered to be >5000 mg/kg bw when rats were treated with Barbituric acid (67-52-7) orally.