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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data from secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Acute oral toxicity for CAS no.67-52-7
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
ChemID plus A TOXNET DATABASE.2017

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: As mention below
Principles of method if other than guideline:
Acute oral toxicity study of Barbituric acid was performed in Rat
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Barbituric acid
Cas Number:
67-52-7
Molecular formula:
C4H4N2O3
IUPAC Name:
Barbituric acid
Details on test material:
- Name of test material (as cited in study report):Barbituric acid
- Molecular formula :C4H4N2O3
- Molecular weight :128.087g/mole
- Substance type:organic
- Physical state:Liquid
Purity:No data available
- Impurities (identity and concentrations):No data available
Specific details on test material used for the study:
- Name of test material (as cited in study report):Barbituric acid
- Molecular formula :C4H4N2O3
- Molecular weight :128.087g/mole
- Substance type:organic
- Physical state:Liquid
- Purity:No data available
- Impurities (identity and concentrations):No data available

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
5000 mg/kg
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
LD50 was considered >5000mg/kg body weight.When rats were treated with Barbituric acid orally.
Executive summary:

Acute oral toxicity study, rats were treated with Barbituric acid orally. No mortality was observed in treated rats at 5000 mg/kg bw. Therefore, LD50 was considered to be >5000 mg/kg bw when rats were treated with Barbituric acid (67-52-7) orally.