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Ecotoxicological information

Toxicity to microorganisms

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Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other: Refer below principle
Principles of method if other than guideline:
Antibacterial activity observed of test substance 1,3-thiazolidine-2,4-dione in bacterial species Pseudomonas aeruginosa UFPEDA 39 strain,Escherichia coli UFPEDA 224 strain,Serratia marcescens UFPEDA 398 strain,Staphylococcus aureus UFPEDA 01 strain,Mycobacterium smegmatis UFPEDA 71 strain,Enterococcus faecalis UFPEDA 138 strain,Micrococcus luteus UFPEDA 06 strain,Bacillus subtilis UFPEDA 16 strain and fungal species Candida albicans UFPEDA 1007 strain at dose concentration 300 μg/disc.
GLP compliance:
not specified
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2,4-Thiazolidinedione
- Molecular formula: C3H3NO2S
- Molecular weight: 117.1277 g/mol
- Substance type: organic
- Physical state: Solid
- Smiles notation: C1C(=O)NC(=O)S1
- InChl: 1S/C3H3NO2S/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
Analytical monitoring:
not specified
Vehicle:
yes
Details on test solutions:
PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Chemical name of vehicle (organic solvent, emulsifier or dispersant):DMSO
Test organisms (species):
other: Pseudomonas aeruginosa,Escherichia coli,Serratia marcescens,Staphylococcus aureus,Mycobacterium smegmatis,Enterococcus faecalis,Micrococcus luteus,Bacillus subtilis and Candida albicans
Details on inoculum:
Pseudomonas aeruginosa UFPEDA 39 strain,Escherichia coli UFPEDA 224 strain,Serratia marcescens UFPEDA 398 strain,Staphylococcus aureus UFPEDA 01 strain,Mycobacterium smegmatis UFPEDA 71 strain,Enterococcus faecalis UFPEDA 138 strain,Micrococcus luteus UFPEDA 06 strain,Bacillus subtilis UFPEDA 16 strain and fungal species Candida albicans UFPEDA 1007 strain
Test type:
not specified
Water media type:
freshwater
Reference substance (positive control):
not specified
Key result
Dose descriptor:
other: MIC
Effect conc.:
300 other: μg/disc
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
other: zone of inhibition
Remarks on result:
other: Value of zone of inhibition is < 7 mm
Validity criteria fulfilled:
not specified
Conclusions:
From Reaxy database the antibacterial activity (MIC) of test chemical 1,3-thiazolidine-2,4-dione i.e 2,4-Thiazolidinedione (Cas no.2295-31-0) was observed at dose concentration 300 μg/disc and value of zone of inhibition is < 7 mm.
Executive summary:

Antibacterial activity observed of test substance 1,3-thiazolidine-2,4-dione (Cas no.2295 -31 -0) in bacterial species Pseudomonas aeruginosa UFPEDA 39 strain,Escherichia coli UFPEDA 224 strain,Serratia marcescens UFPEDA 398 strain,Staphylococcus aureus UFPEDA 01 strain,Mycobacterium smegmatis UFPEDA 71 strain,Enterococcus faecalis UFPEDA 138 strain,Micrococcus luteus UFPEDA 06 strain,Bacillus subtilis UFPEDA 16 strain and fungal species Candida albicans UFPEDA 1007 strain at dose concentration 300 μg/disc.

Based on the experimental observation of antibacterial activity (MIC) the value of zone of inhibition is < 7 mm.

Description of key information

From Reaxy database the antibacterial activity (MIC) of test chemical 1,3-thiazolidine-2,4-dione i.e 2,4-Thiazolidinedione (Cas no.2295-31-0) was observed at dose concentration 300 μg/disc and value of zone of inhibition is < 7 mm.

Key value for chemical safety assessment

Additional information

Antibacterial activity observed of test substance 1,3-thiazolidine-2,4-dione (Cas no.2295 -31 -0) in bacterial species Pseudomonas aeruginosa UFPEDA 39 strain,Escherichia coli UFPEDA 224 strain,Serratia marcescens UFPEDA 398 strain,Staphylococcus aureus UFPEDA 01 strain,Mycobacterium smegmatis UFPEDA 71 strain,Enterococcus faecalis UFPEDA 138 strain,Micrococcus luteus UFPEDA 06 strain,Bacillus subtilis UFPEDA 16 strain and fungal species Candida albicans UFPEDA 1007 strain at dose concentration 300 μg/disc.

Based on the experimental observation of antibacterial activity (MIC) the value of zone of inhibition is < 7 mm.