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Environmental fate & pathways

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Biodegradation in water

Biodegradability of 1,3-thiazolidine-2,4-dione (CAS no. 2295 -31 -0) is predicted using OECD QSAR toolbox version 3.3 (2017) with logKow as the primary descriptor. Test substance undergoes 22.89% degradation by BOD in 28 days.Thus, based on percentage degradation, the test chemical 1,3-thiazolidine- 2,4-dione was estimated to be not readily biodegradable in water.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 1,3 -thiazolidine-2,4 -dione (CAS No. 2295 -31 -0). If released in to the environment, 44.8% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 1,3 -thiazolidine-2,4 -dione in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of 1,3 -thiazolidine-2,4 -dione in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0859%), indicates that 1,3 -thiazolidine-2,4 -dione is not persistent in sediment.

 

Biodegradation in soil

The half-life period of 1,3-thiazolidine-2,4-dione (CAS No. 2295 -31 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 53.2% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 1,3-thiazolidine-2,4-dione in soil is estimated to be 30 days (720 hrs). Based on this half-life value of 1,3-thiazolidine-2,4-dione

, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

Additional information

Biodegradation in water

Various predicted data for the target compound1,3-thiazolidine-2,4-dione(CAS No. 2295-31-0) and various supporting weight of evidence studies for its closest read across substance with logKow as the primary descriptor were reviewed for the biodegradation end point which are summarized as below:

 

In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor, percentage biodegradability of test chemical 1,3-thiazolidine-2,4-dione(CAS No. 2295-31-0) was estimated.Test substance undergoes 22.89% degradation by BOD in 28 days.Thus, based on percentage degradation, the test chemical 1,3-thiazolidine- 2,4-dione was estimated to be not readily biodegradable in water.

 

In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound 1,3-thiazolidine-2,4-dione(CAS No. 2295-31-0) in the presence of mixed populations of environmental microorganisms was estimated.The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 1,3 -thiazolidine-2,4 -dione is expected to be not readily biodegradable.

 

In a supporting weight of evidence study from authoritative database (J-CHECK, 2017) for the read across chemical 1,2,3,6-tetrahydrophthalimide (CAS no. 85-40-5), the read across chemical 1,2,3,6-tetrahydrophthalimide was tested for biodegradation by taking sludge as a inoculums at concentration 30 mg/L for 4 weeks. The initial concentration of chemical taken was 100 mg/L. The study design was of standard type. After 4 weeks percent degradation obtained by taking different parameters in consideration such as BOD, TOC and HPLC were 0%, 3 % and 8% respectively. So it is concluded that the chemical 1,2,3,6-tetrahydro phthalimide of CAS no. 85-40-5 is not readily biodegradable.

 

For the another read across chemical 1,2-dihydropyridazine-3,6-dione (CAS no. 123-33-1) from authoritative database (J-CHECK, 2017), the read across chemical 1,2 -dihydropyridazine-3,6 -dione was tested for biodegradation by taking activated sludge as a inoculums at concentration 30 mg/L for 4 weeks (28 days). The initial concentration of chemical taken was 100 mg/L. The study design was of standard type. After 4 weeks (28 days) percent degradation obtained by taking different parameters  in consideration such as BOD, TOC and HPLC are 6 % , 1% and 1 % respectively. So it is concluded that this test chemical 1,2-dihydropyridazine-3,6-dione ( CAS no. 123-33-1) is not readily biodegradable.

 

On the basis of above results for target chemical1,3-thiazolidine-2,4-dione(from OECD QSAR toolbox version 3.3 and EPI suite, 2017) and for its read across substance (from authoritative database J-CHECK, 2017), it can be concluded that the test substance1,3-thiazolidine-2,4-dionecan be expected to be not readily biodegradable in nature.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 1,3 -thiazolidine-2,4 -dione (CAS No. 2295 -31 -0). If released in to the environment, 44.8% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 1,3 -thiazolidine-2,4 -dione in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of 1,3 -thiazolidine-2,4 -dione in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.0859%), indicates that 1,3 -thiazolidine-2,4 -dione is not persistent in sediment.

 

Biodegradation in soil

The half-life period of 1,3-thiazolidine-2,4-dione (CAS No. 2295 -31 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 53.2% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 1,3-thiazolidine-2,4-dione in soil is estimated to be 30 days (720 hrs). Based on this half-life value of 1,3-thiazolidine-2,4-dione

, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.

On the basis of available information, the test substance 1,3 -thiazolidine-2,4 -dione can be considered to be not readily biodegradable in nature.