But-3-yn-2-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

September 1957

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1958

Report date:

1958

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

But-3-yn-2-ol

EC Number:

217-978-1

EC Name:

But-3-yn-2-ol

Cas Number:

2028-63-9

Molecular formula:

C4H6O

IUPAC Name:

but-3-yn-2-ol

Test animals

Species:

rat

Strain:

other: not specified

Sex:

female

Details on test animals or test system and environmental conditions:

No further details provided

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

50, 10, 2% test substance were administered.

Doses:

10, 20, 40, 50, 63, 79, 100, 126, 500 and 5000 mm3/kg bw (= 0.01 - 5 ml/kg bw)
= 9, 17, 34, 43, 54, 68, 86, 109, 431, 4308 mg/kg bw (Density: 0.8616 g/ml @20°C [CRC, 2008])

No. of animals per sex per dose:

For 5000, 500 and 10 mm3/kg one animal was tested. For the other concentrations (20-126 mm3/kg bw) 5 animals were tested. The sex distribution was not specified.

Control animals:

no

Details on study design:

No further details were provided.

Statistics:

No data provided

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

ca. 45 mg/kg bw

Based on:

test mat.

Remarks on result:

other: original value: ca. 52.6 mm3/kg, mg/kg bw calculated based on density at 20 °C = 0.8616 g/mL (CRC 2008)

Mortality:

See table below.

Clinical signs:

Trembling, apathy, bristled fur, partly lateral position and seizures were observed.
From the animals that died due to treatment, most died within a few hours. Some died one day after administration of the test substance.

Body weight:

No data was provided.

Gross pathology:

No data was provided.

Any other information on results incl. tables

mm3/kg bw	mg/kg bw	dead/ total animals
10	9	0/1
20	17	0/5
40	34	2/5
50	43	4/5
63	54	4/5
79	68	4/5
100	86	4/5
126	109	5/5
500	431	1/1
5000	4308	1/1

LD50 (rat, oral) = 52.6 mm3/kg bw = 45.3 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:

Category 2 based on GHS criteria