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Environmental fate & pathways

Hydrolysis

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Description of key information

Half-lives at pH 4.0, 7.0 and 9.0 and at 25 ºC (as calculated with the Arrhenius equation) are 4.8 days, 113 days and 20 days, respectively. 

Key value for chemical safety assessment

Half-life for hydrolysis:
113 d
at the temperature of:
25 °C

Additional information

A GLP compliant study was performed, according to OECD guideline 111, to determine the abiotic degradation of the test substance by hydrolysis at three different pH values. Hydrolysis of the test substance in pH 4.0, 7.0 and 9.0 sterile buffers was observed at all tested temperatures (20 ± 0.5 °C, 35 ± 0.5 °C and 50 ± 0.5 °C) in the dark, with a half-life range of 0.44 days (pH 4.0 at 50 ºC) to 145 days (pH 7.0, 20 ºC). Based on these results, aqueous abiotic hydrolysis would be expected to contribute to the degradation of the test substance at pH 4.0, 7.0 and 9.0 under the conditions associated with typical use and/or exposure. Half-lives calculated from the Arrhenius equation at pH 4.0, 7.0 and 9.0 at 25 ºC are calculated to be 4.8 days, 113 days and 20 days, respectively.