Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 216-644-2 | CAS number: 1633-22-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- See read-across justification report, attached to "Toxicological information" section.
- Reason / purpose for cross-reference:
- read-across source
- Irritation / corrosion parameter:
- % tissue viability
- Value:
- 106
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Irritation / corrosion parameter:
- % tissue viability
- Value:
- 90
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Interpretation of results:
- other: non-corrosive
- Conclusions:
- Dibenzetano is estimated to be non corrosive.
- Executive summary:
Dibenzetano is estimated to be non corrosive, from the result of the source study (see read-across justification report).
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- See read-across justification report, attached to "Toxicological information" section.
- Reason / purpose for cross-reference:
- read-across source
- Irritation / corrosion parameter:
- % tissue viability
- Value:
- 98.209
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Interpretation of results:
- other: No Category
- Conclusions:
- Dibenzetano is estimated to be non irritant, from the result of the source study. Based on this one the indication of the classification for Dibenzetano is as follows: Globally Harmonized System of Classification and Labelling of Chemicals: No Category.
- Executive summary:
Dibenzetano is estimated to be non irritant, from the result of the source study (see read-across justification report).
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- See read-across justification report, attached to "Toxicological information" section.
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- in vitro irritation score
- Run / experiment:
- corneas treated with 750 mg DPX-C (Di-Cloro-Di-p-Xililene)
- Value:
- 0.42
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Irritation parameter:
- in vitro irritation score
- Run / experiment:
- corneas treated with 750 mg DPX-C (Di-Cloro-Di-p-Xililene) (suspension) at 20% (w/v)
- Value:
- 0.57
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Interpretation of results:
- other: No Category
- Conclusions:
- Dibenzetano is estimated to be non irritant, from the result of the source study. Based on this one, the indication of the classification for Dibenzetano is as follows: Globally Harmonized System of Classification and Labelling of Chemicals: No Category.
- Executive summary:
Dibenzetano is estimated to be non irritant, from the result of the source study (see read-across justification report).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
According to the test performed and to the Regulation (EC) n. 1272/2008, Dibenzetano is not classified as irritating to the skin and to the eye.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
