Registration Dossier
Registration Dossier
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EC number: 436-710-6 | CAS number: 756-13-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: other guideline: EC Directive 2000/32, B13/14 OECD 471, 1997
- GLP compliance:
- yes
- Type of assay:
- other: not available
Test material
- Reference substance name:
- -
- EC Number:
- 436-710-6
- EC Name:
- -
- Cas Number:
- 756-13-8
- Molecular formula:
- C6F12O
- IUPAC Name:
- 1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)pentan-3-one
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: Salmonella typhimurium (TA1535, TA1537, TA100 and TA98) Escherichia coli WP2uvrA
- Metabolic activation system:
- S9 liver homogenate of rat induced with Aroclor 1254.
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 10 ... 5000 μg/plate
Concentration range in the main test (without metabolic activation): 10 ... 5000 μg/plate - Vehicle / solvent:
- Solvent: ethanol
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 μg/plate)
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 μg/plate)
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 μg/plate)
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 μg/plate)
- Additional information on results:
- Observations:
The bacterial background lawn was not reduced at all concentrations tested and no biologically relevant decrease in the number of revertants was observed. The presence of 5 and 10% (v/v) liver microsomal activation did not influence these findings. T-7479 did not induce a dose-related, two-fold increase in the number of revertant (His+) colonies in each of the four tester strains (TA1535, TA1537, TA98 and TA100) and in the number of revertant (Trp+) colonies in tester strain WP2uvrA both in the absence and presence of S9-metabolic activation. These results were confirmed in an independently repeated experiment. - Remarks on result:
- other: Test system: preliminary test
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results
negative with metabolic activation
negative without metabolic activation
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