Registration Dossier

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Report Date:
2002

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: The study was designed to be in compliance with EEC (Annex II, point 5.2.3), OECD 403, US EPA and J-MAFF test guidelines for inhalation studies.
GLP compliance:
yes
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
other: Albino Sprague-Dawley

Administration / exposure

Type of inhalation exposure:
other: Snout only
Vehicle:
other: None
Duration of exposure:
4 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 1 275 mg/L air
Exp. duration:
4 h
Mortality:
Male: CA 1275 mg/L; Number of animals: 5; Number of deaths: 0
Male: 0 mg/L; Number of animals: 5; Number of deaths: 0
Female: CA 1275 mg/L; Number of animals: 5; Number of deaths: 0
Female: 0 mg/L; Number of animals: 5; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: Exagerrated breathing was evident in test rats from 30 minutes into exposure, persisting for at least 2 hours post exposure.
Gross pathology:
Effects on organs:
There were no treatment related findings.

Applicant's summary and conclusion

Interpretation of results:
other: Not classified; Criteria used for interpretation of results: EU