Registration Dossier
Registration Dossier
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EC number: 224-638-6 | CAS number: 4433-79-8
Endpoint summary
Administrative data
Description of key information
Key study similar to OECD 401 (KEY_401_1977_HUNTINGTON_LONZA Report No 0315): 850 mg/kg bw (rat)
Supporting study similar to OECD 401 (NONKEY_401_1974_HOECHST_1974.0200) LD50: 1154 mg/kg bw (rat)
Supporting study following no guideline (NONKEY_401_1973_Consultox_LONZA Report No 0313): >2500 mg/kg bw (rat, range finding study)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 850 mg/kg bw
Additional information
Testing for acute oral toxicity following a protocol similar to OECD standard method revealed an LD50 of 850 mg/kg bw for male and female rats. Another study, similar to OECD standard method, revealed an LD50 value of 1154 mg/kg bw for female rats and did not show a higher sensitivity for males in a pretest. The lower value of 850 mg/kg bw, representing the most sensitive response, was identified to be suitable for classification purpose. Findings of another not OECD conform range finder study (LD50: > 2500 mg/kg bw.) are considered not to be inconsistent with this conclusion.
Justification for classification or non-classification
The derived LD50 value of 850 mg/kg bw meets criteria for classification as Xn, R22 or Acute toxicity - Oral, Cat 4, H302.
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