Reaction product of 2,2'-oxydiethanol and 2-hydroxyethyl acrylate and 2-hydroxyethyl methacrylate and hexan-6-olide and trimethylhexa-1,6-diyl diisocyanate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23-Nov-2015 to 30-Nov-2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

GLP guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Remarks:

Swiss Federal Office of Public Health, Consumer protection directorate, Notification authority for chemicals, Bern, Switzerland

Type of method:

flask method

Key result

Water solubility:

59.4 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

1 g/L

Incubation duration:

3 d

Temp.:

30 °C

pH:

6.2

Results

 

Preliminary test

The preliminary test indicated a water solubility of <1g/L.

 

Definitive test

The water solubility of RCX 14-848 was determined according to TG OECD 105.

Several test vessels containing ultra-pure water mixed with test item in great excess (initial amount of test item about 1 g per litre water), were incubated and stirred for different periods of time at 30 °C (saturation phase), and then transferred at 20 °C for 24 h (equilibration phase). A sample from each test vessel was subsequently filtered with glass fibre filter and the concentration of test item in the clear aqueous phase was determined with HPLC. The obtained data is summarized in Table 2.

 

Table 2: HPLC determinations in the definitive test

  

				Determined concentrations (mg/L)
test vessel	days at 30 °C	hours at 20 °C	pH	measurement A	measurement B	measurement C	Mean	RSD of replicate measurements
1	1	24	6.1	51.1*	60.4	59.2	59.8	1.32%
2	2	24	6.2	58.7	60.3	59.8	59.6	1.36%
3	3	24	6.4	58.9	59.0	58.6	58.8	0.32%
						Mean	59.4
						RSD	0.8%

 

*outlier, not used for calculation of mean

RSD: relative standard deviation

 

No significant variation of the concentrations in the 3 respective test vessels was observed after 1, 2 and 3 days of incubation at 30 °C (followed by 24 h equilibration at 20 °C).

 

The water solubility of RCX 14-848, calculated as the mean of the three vessels, is 59.4 mg/L at pH 6.2 and 20 °C.

Description of key information

Water solubility = 59.4 mg/L at pH 6.2 and 20 °C (OECD 105, A.6.)

Key value for chemical safety assessment

Water solubility:

59.4 mg/L

at the temperature of:

20 °C

Additional information

The water solubility of the test item was determined using the flask method (with HPLC analysis) according to OECD 105 and EU Method A.6.