Registration Dossier
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EC number: 944-336-4 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14-Jul-2015 to 09-Sep-2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Hess. Ministerium für Umwelt, Energie, Landwirtschaft und Verbraucherschutz, Wiesbaden, Germany
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.35
- Temp.:
- 20 °C
- Remarks on result:
- not measured/tested
- Remarks:
- The pH value at time of measurement was not provided.
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.76
- Temp.:
- 20 °C
- Remarks on result:
- not measured/tested
- Remarks:
- The pH value at time of measurement was not provided.
Reference
Results
The tables show the measured retention times of both test item peaks and the calculated log Pow values for both measurement series.
Retention times of the 1st test item peak
test item |
tR |
k |
log k |
Log Pow |
Pow |
1st measurement |
11.274 |
6.398 |
0.806 |
3.35 |
2237 |
2nd measurement |
11.282 |
6.403 |
0.806 |
3.35 |
2253 |
mean value |
3.35 |
2245 |
|||
standard deviation |
< 0.01 |
12 |
|||
Retention times of the 2nd test item peak
test item |
tR |
k |
log k |
Log Pow |
Pow |
1stmeasurement |
15.813 |
9.376 |
0.972 |
3.76 |
5740 |
2ndmeasurement |
15.824 |
9.383 |
0.972 |
3.76 |
5767 |
mean value |
3.76 |
5763 |
|||
standard deviation |
< 0.01 |
19 |
|||
According to the HPLC measurements the test item consists of two UV active main components. Therefore the test item has two partition coefficients at 20 °C:
1st log Pow = 3.35 +< 0.01
2nd log Pow = 3.76 +< 0.01
Description of key information
log Pow = 3.35 and 3.76 at 20 °C (OECD 117, A.8.)
Key value for chemical safety assessment
Additional information
The partition coefficient of the test item was determined using the HPLC method according to OECD 117 and EU Method A.8.
According to the HPLC measurements the test item consists of two UV active main components. Therefore the test item has two log Pow coefficients at 20 °C, 3.35 and 3.76.
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