Registration Dossier
Registration Dossier
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EC number: 231-493-2 | CAS number: 7585-39-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No hydrolyses of .beta.-cyclodextrin will appear in case of an acidic environment in humans. When radioactively spiked material is administered orally to rats in a metabolism study it was metabolized more slowly as starch as indicated by the carbon dioxide exhaled (up to 67% of the radioactivity). Only minor portions were found in the urine and the faeces (up to 5% each). Only minor traces were found in the other organs. (Andersen 1963). When labelled .beta.-Cyclodextrin with a purity of more than 77% is administered to rats the peak blood level of radioactivity is observed 4 to 11 hours after administration. Compared to glucose the respired radioactivity was similar at the low dose group whereas at the higher dose the percentage of respired radioactivity was less. .Beta.-cyclodextrin is not absorbed from the stomach or small intestine to a measurable extend. Hydrolysis occurs in the large intestine by the gut microorganisms up to a level of saturation. Unabsorbed material is excreted in faeces. (Szejtli 1980; Gerlóczy 1981 and 1985).
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