Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report Date:
1979

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Method in Federal Register 38(187)1500.41, S.27029,1973.
GLP compliance:
no
Remarks:
study pre-dates GLP introduction

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
impurity
Test material form:
liquid
Specific details on test material used for the study:
Product: 2,6-Dimethylheptanol -2 (liquid)
Substance No.: 77/278

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Details on study design:
Primary eye irritation was measured in 6 rabbits. Readings at 24, 48 & 72 hrs and 8 days.

Results and discussion

In vivo

Results
Remarks on result:
probability of moderate irritation
Irritant / corrosive response data:
Primary irritation index: 536 / 18 = 29.8
The pathological findings on the eye and the irritations on the mucous membrane were not reversible within 8 days. Based on the findings the substance must be considered to be moderately irritant.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
Based on the findings the substance must be considered to be moderately irritant.