Registration Dossier

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report Date:
1979

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Method in Federal Register 38(187)1500.41, S.27019,1973.
GLP compliance:
no
Remarks:
study pre-dates GLP introduction

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
impurity
Test material form:
liquid
Specific details on test material used for the study:
Product: 2,6-Dimethylheptanol -2 (liquid)
Substance No.: 77/278

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)

Results and discussion

In vivo

Results
Remarks on result:
probability of moderate irritation
Irritant / corrosive response data:
Primary irritation index: 20.5 / 4 = 5.13
Alterations were observed already after a short period of exposure. The irritations were reversible within 8 days after a short period of exposure, but not so after a 24-hour exposure. Based on the findings the substance must be considered to be strongly irritant (light redness and swelling. Flaking and overlapping redness were observed.)

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
Based on the findings the substance must be considered to be moderately irritant.