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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Description of key information

The growth inhibition of algae was determined using a validated QSAR for the Mode of Action in question, (MOA 1, non-polar narcosis). The predicted 72-hour ErC50 value is 23.77 mg/L (95% confidence limits of 21.01 - 26.89 mg/L).

Key value for chemical safety assessment

EC50 for freshwater algae:
23.77 mg/L

Additional information

The predicted algae 72h EC50 value is reliable since the test substance falls within the applicability domain of the model. The water solubility value (used as input into the model) of the test substance is within the descriptor domain of the model which is between log water solubility (in log (mol/L)) of -4.70 to 0.87. Moreover the iSafeRat® prediction of Dimetol for acute toxicity to Fish is extremely close to the experimentally measured value providing strong supporting evidence that Dimetol is a MOA 1 substance as expected from its chemical structure. Therefore, this algae endpoint value can be considered valid for use in risk assessment and classification and labelling.