Registration Dossier
Registration Dossier
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EC number: 205-429-9 | CAS number: 140-73-8
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From August 10 to 16, 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 2004
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- 2008
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- other: acetonitrile:water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- ca. 1.87
- Temp.:
- 25 °C
- pH:
- ca. 5
- Remarks on result:
- other:
- Remarks:
- 95% confidence limits: 1.69–2.03
- Details on results:
- Two determinations of the log Pow value of the test substance were conducted: first by injecting each reference and test item separately, secondly by injecting all the reference and test items together.
The retention time of the test substance was 5.56 min in the single injection run and 5.57 in the mixed injection run.
The log POW value for the test substance at a pH of 5.0 was determined to be 1.86 (95% confidence limits: 1.69-2.03) in the single injection run and 1.87 (95% confidence limits: 1.69-2.03) in the mixed injection run. - Conclusions:
- LogPow = 1.87
- Executive summary:
Method
The log Pow of the test substance was determined according to the OECD guideline 117. This determination is based upon a regression analysis of the log Pow values of reference items against their respective retention times as determined by HPLC analysis. The log Pow was determined at the environmentally relevant pH of 5.0.
Results
The log Pow value of the test substance, calculated as the mean of two determinations, is 1.87 (95% confidence limits: 1.69–2.03) at a pH of 5.0.
Reference
Description of key information
LogPow = 1.87
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.87
- at the temperature of:
- 25 °C
Additional information
The log Pow of the test substance was determined according to the OECD guideline 117. This determination is based upon a regression analysis of the log Pow values of reference items against their respective retention times as determined by HPLC analysis. The log Pow was determined at the environmentally relevant pH of 5.0.
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