Registration Dossier
Registration Dossier
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EC number: 203-459-7 | CAS number: 107-07-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets scientific standards with acceptable restrictions (no details about the test substance)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- LD50 in mice
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-chloroethanol
- EC Number:
- 203-459-7
- EC Name:
- 2-chloroethanol
- Cas Number:
- 107-07-3
- Molecular formula:
- C2H5ClO
- IUPAC Name:
- 2-chloroethan-1-ol
- Details on test material:
- No details
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- 1 and 2% aqueous solution
- Doses:
- 50, 64, 80, 100, 125 µl/kg bw
- No. of animals per sex per dose:
- 5
- Details on study design:
- Post exposure observation period 14 days
Necropsy performed
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 120 mg/kg bw
- Mortality:
- Males more sensitive than females
- Clinical signs:
- >= 100 µl/kg bw: symptoms immediately after injection like increased respiration rate, then hunching position, atony, twitching, staggered gait, apathy, side or prone position; survivors without symptoms at day 4
<=80 µl/kg bw: increased respiration rate, hunching position, staggered gait; survivors without symptoms at day 3 - Gross pathology:
- greyish liver
Applicant's summary and conclusion
- Conclusions:
- LD50 in male and female mice combined was ca. 120 mg/kg bw after i.p. injection.
- Executive summary:
Study meets scientific standards.
Five male and 5 female mice were i.p. injected with 50, 64, 80, 100, or 125 µl/kg bw; the post exposure observation period was 14 days. Clinical signs occurred immediately after injection. Males were more sensitive than females.
Conclusion: The LD50 in male and female mice combined was ca. 120 mg/kg bw after i.p. injection.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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