Registration Dossier
Registration Dossier
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EC number: 701-090-0 | CAS number: -
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: aim of the study was liver iron content determination after oral feed
Data source
Reference
- Title:
- No information
- Author:
- Van Wyk CP, Robbins DJ (1974), Liver iron contents in rats after administration of certain iron compounds, South African Med J 48, 505-509.
Materials and methods
Test material
- Reference substance name:
- Diiron trioxide
- EC Number:
- 215-168-2
- EC Name:
- Diiron trioxide
- Cas Number:
- 1309-37-1
- Molecular formula:
- Fe2O3
- IUPAC Name:
- Diiron trioxide
- Details on test material:
- IUCLID4 Test substance: other TS: Fe2O3 (no data on purity)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: BDV BDIX
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- 21 days
- Frequency of treatment:
- daily (feeding study)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
112.3, 186.3, 265.5, 330.1 mg/100g diet
Basis:
other: iron intake (mg/100 g average body mass)
- No. of animals per sex per dose:
- 4 per dose
- Control animals:
- yes
- Details on study design:
- Post-exposure period: no
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Average iron intake 1120 to 3300 mg/kg body mass; no increase of liver non-hemoglobin iron content
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
