Registration Dossier
Registration Dossier
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EC number: 701-090-0 | CAS number: -
Immunotoxicity
Administrative data
- Endpoint:
- immunotoxicity
- Remarks:
- acute
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented and scientifically acceptable
Data source
Reference
- Reference Type:
- publication
- Title:
- The effects of intratracheally administered coarse mode particles on the respiratory tract infection in mice
- Author:
- Aranyi C, Graf JL, O`Shea WJ, Graham J, Miller FJ
- Year:
- 1 983
- Bibliographic source:
- Toxicol. Letters 19: 63-72
Materials and methods
- Principles of method if other than guideline:
- Saline suspensions of Fe2O3 were intratracheally injected at the 3 dose levels of 10, 33 and 100 µg per mouse. Control mice received saline. There were 24 mice in each dose group (including controls), and each study was replicated 3 times. Exposed and control mice were simultaneously challenged with aerosols of viable Group C Streptococcus sp. After the challenge, deaths were recorded daily over a 14 day observation period.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diiron trioxide
- EC Number:
- 215-168-2
- EC Name:
- Diiron trioxide
- Cas Number:
- 1309-37-1
- Molecular formula:
- Fe2O3
- IUPAC Name:
- Diiron trioxide
- Details on test material:
- Pfizer, 9998R; phase purity: > 99% hematite, < 0.5% magnetite
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- female
Administration / exposure
- Route of administration:
- intratracheal
- Vehicle:
- physiological saline
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- single injection
- No. of animals per sex per dose:
- 24
Results and discussion
Any other information on results incl. tables
Mortality was significantly increased in treated animals
Control: ~37%
Treated: ~60%
No dose/effect relation could be detected
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
