Registration Dossier
Registration Dossier
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EC number: 807-710-7 | CAS number: 532410-39-2
Endpoint summary
Administrative data
Description of key information
The skin sensitization of the targetcompoundwas predicted employing two differentin silicoapproaches: the QSAR statistical model as provided by Vega and the decision rule system provided by Toxtree and Derek Nexus.
The three predictors were employed in order to apply a weight of evidence (WoE) approach to enhance the reliability of the prediction.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
In the weight of evidence assessment only reliable predictions are to be taken into account.
In the case of the targetTert-Butyl methyl(2-oxopropyl)carbamate, Vega predicted the target compound as sensitizer but the prediction was assessed as low reliable,Toxtree identified an alert for Acyl Transfer agent but identified no protein binding alerts and Derek Nexus identified no alerts.
Thus the target compound Tert-Butyl methyl(2-oxopropyl)carbamate was predicted asnot sensitizer for the skin but a reliability assessment was not possible.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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