Reaction mass of (3R)-3-[(1R)-4-methyl-3-cyclohexen-1-yl]butanal and (3S)-3-[(1R)-4-methyl-3-cyclohexen-1-yl]butanal

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

01 September - 07 December 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Study conducted in accordance with international guidelines and in accordance with GLP. All relevant validity criteria were met.

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7200 (Melting Point / Melting Range)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Specific details on test material used for the study:

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature
- Stability under test conditions: Assumed stable.
- Solubility and stability of the test substance in the solvent/vehicle: N/A
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: N/A

Key result

Melting / freezing pt.:

< -80 °C

Atm. press.:

1 025 hPa

During cooling of the first experiment, no effects were observed which were due to crystallization of the test item.

 

To further investigate the melting temperature of the test item, two subsamples of the test item were stored for 20 hours at -23.4 ± 0.4 °C and at -81.5 ± 3.0 °C respectively. It was observed after storage that the test item was a viscous liquid (-20 °C freezer) and a very viscous liquid (-80 °C freezer). According to this it was concluded that the melting temperature of the test item is < -80 °C (< 193 K).

Conclusions:

The melting/ freezing temperature of the test substance has been determined to be < -80 ºC.

Executive summary:

The melting/ freezing temperature was determined using EU Method A.1 and Differential Scanning Calorimetry. During the cooling phase no effects were observed that were due to crystallisation of the test substance. According to the results it was concluded that the melting temperature of the test substance is < -80 ºC (< 193 K) at atmospheric pressure (1025 hPa).

Description of key information

MP: < -80 ºC at 1025 hPa, EU Method A.1 - Differential Scanning Calorimetry method, Anon, 2017.

Additional information

The melting/ freezing temperature was determined using EU Method A.1 and Differential Scanning Calorimetry. During the cooling phase no effects were observed that were due to crystallisation of the test substance. According to the results it was concluded that the melting temperature of the test substance is < -80 ºC (< 193 K) at atmospheric pressure (1025 hPA).