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Environmental fate & pathways

Biodegradation in water: screening tests

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Reference
Endpoint:
biodegradation in water: ready biodegradability
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Internationally accepted calculation method, EPI-Suite EPA (USA).
Guideline:
other: REACH Guidance on QSARs R.6
Principles of method if other than guideline:
Calculation by EPI-Suite BIOWIN v4.10.
GLP compliance:
no
Specific details on test material used for the study:
SMILES : CN(C)C3CC(C)OC(OC2C(C)C(OC1CC(C)(OC)C(O)C(C)O1)C(C)C(=O)OC(CC)C(C)(O)C(O)C(C)C(=NO)C(C)CC2(C)OC)C3O
Details on study design:
Estimated by calculation
Key result
Parameter:
not specified
Remarks on result:
not readily biodegradable based on QSAR/QSPR prediction

Probability of Rapid Biodegradation (BIOWIN v4.10):

Biowin1 (Linear Model)        : -1.8065

Biowin2 (Non-Linear Model)    :  0.0000

Expert Survey Biodegradation Results:

Biowin3 (Ultimate Survey Model):  1.1900 (recalcitrant)

Biowin4 (Primary Survey Model) :  2.5575 (weeks-months)

MITI Biodegradation Probability:

Biowin5 (MITI Linear Model)   : -0.3027

Biowin6 (MITI Non-Linear Model):  0.0000

Anaerobic Biodegradation Probability:

Biowin7 (Anaerobic Linear Model): -3.0711

Ready Biodegradability Prediction:  NO

Validity criteria fulfilled:
not applicable
Interpretation of results:
not readily biodegradable
Conclusions:
The substance is predicted not to be readily biodegradable by EPI-Suite BIOWIN v4.10.
Executive summary:

The substance is predicted not to be readily biodegradable by EPI-Suite BIOWIN v4.10.

Description of key information

Key study: Internationally accepted calculation method, EPI-Suite EPA (USA). The substance is predicted not to be readily biodegradable by EPI-Suite BIOWIN v4.10.

Key value for chemical safety assessment

Biodegradation in water:
under test conditions no biodegradation observed

Additional information