Registration Dossier
Registration Dossier
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EC number: 230-597-5 | CAS number: 7212-44-4
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The Effects of Terpenoids and other olized Dietary Anutrients on Hepatic Drug-Metabolizing Enzymes
- Author:
- Parke DV and Rahman H
- Year:
- 1 969
- Bibliographic source:
- Biochem J 113 (2): 12
- Reference Type:
- secondary source
- Title:
- The Effects of Terpenoids and other olized Dietary Anutrients on Hepatic Drug-Metabolizing Enzymes
- Author:
- Parke DV and Rahman H
- Year:
- 1 969
- Bibliographic source:
- Report to RIFM (Location 1841 )
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- The study was conducted to investigate the effect of the test material on the activities of the hepatic drug metabolizing enzymes.
- GLP compliance:
- no
- Remarks:
- ; GLP was not compulsory at the time the study was conducted.
Test material
- Reference substance name:
- 3,7,11-trimethyldodeca-1,6,10-trien-3-ol,mixed isomers
- EC Number:
- 230-597-5
- EC Name:
- 3,7,11-trimethyldodeca-1,6,10-trien-3-ol,mixed isomers
- Cas Number:
- 7212-44-4
- Molecular formula:
- C15H26O
- IUPAC Name:
- 3,7,11-trimethyldodeca-1,6,10-trien-3-ol
- Details on test material:
- - Name of test material (as cited in study report): Nerolidol, isomers unknown
- Analytical purity: no data given
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: oral feed or i.v.
- Vehicle:
- not specified
- Details on exposure:
- Rats were pretreated for 3 days with nerolidol administered by intraperitoneal injection or by admixture with their food.
- Duration and frequency of treatment / exposure:
- 3 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
no data given
- No. of animals per sex per dose / concentration:
- no data given
- Control animals:
- not specified
- Details on study design:
- Biphenyl 4-hydroxylase, glucuronyl transferase and 4-nitrobenzoate reductase activities and cytochrome P-450 were determined in 10000g supernatants of the liver homogenates.
Results and discussion
- Preliminary studies:
- no data given
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- no data given
- Details on distribution in tissues:
- no data given
- Details on excretion:
- no data given
Metabolite characterisation studies
- Metabolites identified:
- no
- Details on metabolites:
- The authors stated that the test material is metabolized by reduction and conjugation with glucuronic acid
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
