Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
other: observations in humans
Adequacy of study:
weight of evidence
Study period:
1995-1997
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Observations were made in workers by the company physician; limited reporting.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1995

Materials and methods

Type of sensitisation studied:
skin
Study type:
case report
Test guideline
Qualifier:
no guideline required
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-bis(3-methyl-2,5-dioxo-1H-pyrrolinylmethyl)benzene
EC Number:
412-570-1
EC Name:
1,3-bis(3-methyl-2,5-dioxo-1H-pyrrolinylmethyl)benzene
Cas Number:
119462-56-5
Molecular formula:
Hill formula: C18 H16 N2 O4
IUPAC Name:
3-methyl-1-({3-[(3-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]phenyl}methyl)-2,5-dihydro-1H-pyrrole-2,5-dione

Method

Type of population:
occupational

Results and discussion

Results of examinations:
Skin reactions in workers indicated that the material should be regarded as sensitiser to human skin.

Any other information on results incl. tables

Based on the survey, it was concluded that several workers exposed to the material showed complaints and reactions pointing at sensitisation. Following installment of safety measures, the number of complaints related to sensitisation decreased.

Applicant's summary and conclusion

Conclusions:
Based on complaints in workers it was concluded that Perkalink 900 is a sensitiser in humans.