Registration Dossier
Registration Dossier
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EC number: 203-856-5 | CAS number: 111-30-8
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable publication
Data source
Reference
- Reference Type:
- publication
- Title:
- The interaction of DNR and glutaraldehyde with cell membrane proteins leads to morphological changes in erythrocytes
- Author:
- Marczak A, Jozwiak S
- Year:
- 2 008
- Bibliographic source:
- Cancer Letters 260: 118–126
Materials and methods
- Type of study / information:
- In this study, the effects of Daunorubcin and glutaraldehyde on isolated erythrocyte membrane proteins were examined.
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- no
Test material
- Reference substance name:
- Glutaral
- EC Number:
- 203-856-5
- EC Name:
- Glutaral
- Cas Number:
- 111-30-8
- Molecular formula:
- C5H8O2
- IUPAC Name:
- glutaraldehyde
- Test material form:
- liquid
Constituent 1
Results and discussion
Any other information on results incl. tables
It was observed that glutaraldehyde caused in concentration dependent manner an increase of percent of DNR linked to cell membrane proteins. After this incorporation, perturbations in the protein content of cell membranes were observed. The protein aggregates and changes in the level of spectrin, actin and band 3 protein were noted. Due to the changes in spectrin, which is mainly responsible for maintenance of the discocyte shape of erythrocytes, flow cytometry and microscopy techniques were used to control the size and shape of erythrocytes after treatment with DNR and glutaraldehyde. The disturbances in the shape and size of erythrocytes were observed for all tested concentrations of glutaraldehyde. For all tested concentrations of glutaraldehyde, the changes were statistically significant.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
