Glutaral

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable data

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Odor and chemesthesis from exposures to glutaraldehyde vapor

Author:

Cain WS, Schmidt R, Jalowayski AA

Year:

2007

Bibliographic source:

Int. Arch Occup. Environ. Health 80(8): 721-31

Reference 2

Reference Type:

study report

Title:

Unnamed

Year:

2006

Report date:

2006

Materials and methods

Type of study / information:

Assessment of olfactory and chemesthetic sensitivity (feel, sensory irritation) to vapour of glutaraldehyde in young adult females. For chemesthetic sensitivity, assessment included the variable of duration, with focus on whether concentrations initially too low to evoke feel in the eye or upper airway might do so in exposures up to 15 minutes.

Endpoint addressed:

not applicable

Principles of method if other than guideline:

Not applicable

GLP compliance:

no

Remarks:

not applicable

Test material

Test material information

Constituent 1

Reference substance name:

Glutaral

EC Number:

203-856-5

EC Name:

Glutaral

Cas Number:

111-30-8

Molecular formula:

C5H8O2

IUPAC Name:

glutaraldehyde

Test material form:

liquid

Specific details on test material used for the study:

- Name of test material (as cited in study report): Glutaraldehyde
- Physical state: liquid
- Analytical purity: The stimulus material consisted of glutaraldehyde (Fisher Certified, 26.1% by weight in water)
- Lot/batch No.: lot #001197
- Other: Odor: green apple

Method

Ethical approval:

confirmed and informed consent free of coercion received

Details on study design:

Odor and chemesthesis from exposure to glutaraldehyde was tested in volunteer subjects (50 females, 18 -35 years, various ethnicity).
Exposure was brief (up to 5 sec. and 15 min. at concentrations of 0.039 to 4.95 ppb and 229 to 772 ppb for brief exposure and 35 to 100 ppb for 15 min. exposure.

Exposure assessment:

measured

Details on exposure:

Experiment 1:
The first experiment probed sensitivity with forced-choice testing of detection over ranges of concentrations appropriate to three endpoints: odor, feel in the eye, and feel in the nose. A subject participated in hours of testing per endpoint to yield enough data to erect a psychometric (concentration-response) function. Exposure in Experiment 1 entailed use of a vapor-delivery system that stimulated sites of interest separately.

Experiment2:
Exposure in Experiment 2 occurred in the ambient environment of a chamber, with the sites stimulated simultaneously. In that case, subjects rated confidence by the minute that they felt the presence of vapor in the eyes, nose, and throat during exposures of 15 minutes to 35, 50, 75, and 100 ppb, a blank, and an odor control of mild heptane.

Results and discussion

Results:

In Experiment 1, the typical subject achieved 50% detection (threshold) of odor at 0.3 ppb. The typical subject achieved 50% detection of feel in the eye and nose at 390 and 470 ppb, respectively. Psychometric functions for feel showed much sharper dependence on concentration than those for odor.
In Experiment 2, confidence in detection of feel migrated progressively away from no-with certainty toward the zone of uncertainty, with bigger change when the exposures contained any glutaraldehyde. The ratings of confidence failed, however, to show distinguish among these concentrations.