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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: SNIF file in pdf format received from ECHA

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1990

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Approximately Annex V (test substance applied to corneal surface)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
405-370-0
EC Name:
-
Cas Number:
6334-25-4
Molecular formula:
C14H28N2O6
IUPAC Name:
N,N,N',N',-tetrakis(2-hydroxyethyl)hexanediamide
Test material form:
solid: particulate/powder

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Amount / concentration applied:
100 mg
Number of animals or in vitro replicates:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Remarks:
redness
Basis:
mean
Time point:
other: 0
Remarks on result:
other: Max. duration: h; Max. value at end of observation period
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 0
Remarks on result:
other: Max. duration: h; Max. value at end of observation period
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 0
Remarks on result:
other: Max. duration: h; Max. value at end of observation period
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 0
Remarks on result:
other: Max. duration:h;Max. value at end of observation period
Other effects:
No signs of eye irritation were observed at any time during the study

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information
Executive summary:

Note: All info and data in this end point / section is according to ECHA data as annex of inquiry no 06 -0000021150 -88 -0000