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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Experiments were conducted by trusted and reliable laboratory.

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1990

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V (Limit test)
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
405-370-0
EC Name:
-
Cas Number:
6334-25-4
Molecular formula:
C14H28N2O6
IUPAC Name:
N,N,N',N',-tetrakis(2-hydroxyethyl)hexanediamide
Test material form:
solid: particulate/powder

Test animals

Species:
other: Rabbit ( New Zealand White )

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: Substance ground and moistened with 0.85% saline

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Mortality:
Male: 5000 mg/kg bw; number of animals:6; Number of death:0
Female: 5000 mg/kg bw; Number of animals: 6; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
No deaths and no sign of systemic toxicity were observed.
Erythema was observed on day 1, but was not scored. (Body weight loss of 5-25% was seen in 2 animals during the first week; this was attributed to stress produced by the collars worn throughout the study).
Body weight:
see above
Gross pathology:
Effects on organs:
No treatment-related macroscopic findings were observed in internal organs.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

Data for this end point was supplied by ECHA under SNIF#001 -4.1.30 -01