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EC number: 219-989-7 | CAS number: 2592-95-2
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two hydrolysis studies as-
2., 3. and 4. - GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Temp.:
- 55 °C
- Remarks:
- 2. The study was performed at pH range 5-9, respectively.
- Duration:
- 5 d
- Temp.:
- 50 °C
- Remarks:
- 3. The study was performed at pH 4.0, 7.0 and 9.0, respectively.
- Remarks:
- 4. Other details not known
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- Temp.:
- 55 °C
- DT50:
- > 29 - < 146 d
- Remarks on result:
- other: 2. The study was performed at pH range 5-9, respectively.
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Remarks on result:
- other: 3. The study was performed at pH 4.0, 7.0 and 9.0, respectively.
- DT50:
- 1.1 d
- Remarks on result:
- other: 4. Other details not known
- Details on results:
- 2. Details not known
3. Percentage degradation of test chemical was determined to be 3.91%, 1.085% and 4.78% at pH 4.0, 7.0 and 9.0 & at a temperature of 50°C, respectively. Since the chemical is not degradable less than 10 % in this test condition, It is presumably stable in water.
4. The half-life of test chemical is much longer in stagnant waters or groundwaters due to limited volatilization, aerobic biodegradation and photochemical decomposition. Under field conditions, in running water, the half-life of test chemical was estimated to be 1.1 days. - Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 1.1 days to > 1 yr, at pH range 5-9 & temperature of 50-55°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
- Executive summary:
Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:
The half-life value of test chemical was determined at a pH range 5-9 and at a temperature of 55°C, respectively. The estimated half-life value of test chemical was determined to be ranges from 29 to 146 days, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
In an another study, the half-life of the test chemical was determined.The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH). Percentage degradation of test chemical was determined to be 3.91%, 1.085% and 4.78% at pH 4.0, 7.0 and 9.0 & at a temperature of 50°C, respectively and the half-life value of test chemical was determined to be > 1 yr. Since the chemical is not degradable less than 10 % in this test condition, it is presumably stable in water.Thus based on this, test chemical is considered to be not hydrolysable in water.
For the test chemical, the half-life of the test chemical was determined. The half-life value of test chemical was determined to be 1.1 days. Thus based on the value, test chemical is considered to undergoe slow hydrolysis in water.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 1.1 days to > 1 yr, at pH range 5-9 & temperature of 50-55°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
Reference
Description of key information
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 1.1 days to > 1 yr, at pH range 5-9 & temperature of 50-55°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
Key value for chemical safety assessment
Additional information
Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:
The half-life value of test chemical was determined at a pH range 5-9 and at a temperature of 55°C, respectively. The estimated half-life value of test chemical was determined to be ranges from 29 to 146 days, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
In an another study, the half-life of the test chemical was determined. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH). Percentage degradation of test chemical was determined to be 3.91%, 1.085% and 4.78% at pH 4.0, 7.0 and 9.0 & at a temperature of 50°C, respectively and the half-life value of test chemical was determined to be > 1 yr. Since the chemical is not degradable less than 10 % in this test condition, it is presumably stable in water. Thus based on this, test chemical is considered to be not hydrolysable in water.
For the test chemical, the half-life of the test chemical was determined. The half-life value of test chemical was determined to be 1.1 days. Thus based on the value, test chemical is considered to undergoe slow hydrolysis in water.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 1.1 days to > 1 yr, at pH range 5-9 & temperature of 50-55°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is not hydrolysable in water.
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